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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:64050
Term: N-desmethylclozapine
Definition: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
Chemical ID: MESH:C058272
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2adecreases expressionEXP 6480464CTDnorclozapine results in decreased expression of HTR2A proteinPMID:14751426
Htr2adecreases expressionISOHTR2A (Homo sapiens)6480464CTDnorclozapine results in decreased expression of HTR2A mRNAPMID:14751426
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