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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2521
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd3
Name: dopamine receptor D3
Acc ID: CHEBI:64001
Term: N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol
Definition: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a 3-methylphenyl substituent at position 1, a methyl substituent at position 3, a chloro substituent at position 6 and two hydroxy substituents at positions 7 and 8. Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonising the behavioral effects of cocaine.
Chemical ID: MESH:C080703
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd3multiple interactionsEXP 6480464CTD1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]; SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]; SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]PMID:19217379
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