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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2518
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd1
Name: dopamine receptor D1
Acc ID: CHEBI:63988
Term: N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol
Definition: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, an allyl substituent at position 3 and two hydroxy substituents at positions 7 and 8. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
Chemical ID: MESH:C067114
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd1multiple interactionsISODRD1 (Homo sapiens)6480464CTDSK&F 77434 binds to and results in increased activity of DRD1 proteinPMID:15985612
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