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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737148 Species: Homo sapiens RGD Object: Gene Symbol: MSMO1 Name: methylsterol monooxygenase 1

Acc ID: CHEBI:63959 Term: celastrol Definition: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). CasRN: 34157-83-0 Chemical ID: MESH:C050414

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	tripterine results in increased expression of MSMO1 mRNA	PMID:17010675