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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:63959
Term: celastrol
Definition: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Chemical ID: MESH:C050414
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDcelastrol results in increased cleavage of CASP9 proteinPMID:21466843 PMID:27374097
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDcelastrol results in increased expression of CASP9 mRNAPMID:27374097
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDUridine inhibits the reaction [celastrol results in increased cleavage of CASP9 protein]PMID:27374097
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