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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3717
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc8a1
Name: solute carrier family 8 member A1
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc8a1increases response to substanceISOSLC8A1 (Homo sapiens)6480464CTDSLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)PMID:16009740
Slc8a1multiple interactionsISOSLC8A1 (Homo sapiens)6480464CTD2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]; Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]PMID:16009740
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