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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases expressionEXP 6480464CTDChlorodiphenyl (54% Chlorine) results in decreased expression of CYP2E1 mRNA; Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP2E1 proteinPMID:3113478 PMID:8471063
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDChlorodiphenyl (54% Chlorine) results in decreased expression of CYP2E1 mRNAPMID:17851650
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