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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2586
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F2r
Name: coagulation factor II (thrombin) receptor
Acc ID: CHEBI:63791
Term: lenalidomide
Definition: A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Chemical ID: MESH:C467567
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2rdecreases expressionISOF2R (Homo sapiens)6480464CTDlenalidomide results in decreased expression of F2R mRNA; lenalidomide results in decreased expression of F2R proteinPMID:15618473
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