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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094 Species: Homo sapiens RGD Object: Gene Symbol: PCNA Name: proliferating cell nuclear antigen

Acc ID: CHEBI:63632 Term: topotecan Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. CasRN: 123948-87-8 Chemical ID: MESH:D019772

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Topotecan results in decreased expression of PCNA protein	PMID:15923621