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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDTopotecan results in increased activity of CASP9 proteinPMID:19812371
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDTopotecan results in increased cleavage of CASP9 proteinPMID:19812371
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDAPAF1 promotes the reaction [Topotecan results in increased cleavage of CASP9 protein]PMID:19812371
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