• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200 Species: Rattus norvegicus RGD Object: Gene Symbol: Bcl2l1 Name: Bcl2-like 1

Acc ID: CHEBI:63632 Term: topotecan Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. CasRN: 123948-87-8 Chemical ID: MESH:D019772

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1552009	6480464	CTD	APAF1 promotes the reaction [Topotecan results in increased degradation of BCL2L1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of BCL2L1 protein] TRP53 inhibits the reaction [Topotecan results in increased degradation of BCL2L1 protein]	PMID:19812371
increases degradation	ISO	RGD:1552009	6480464	CTD	Topotecan results in increased degradation of BCL2L1 protein	PMID:19812371