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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621087 Species: Rattus norvegicus RGD Object: Gene Symbol: Socs3 Name: suppressor of cytokine signaling 3

Acc ID: CHEBI:63618 Term: pravastatin Definition: A carboxylic ester resulting from the formal condensation or (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. CasRN: 81093-37-0 Chemical ID: MESH:D017035

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:730834	6480464	CTD	Pravastatin results in increased expression of SOCS3 protein	PMID:19330073