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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476 Species: Rattus norvegicus RGD Object: Gene Symbol: Mki67 Name: antigen identified by monoclonal antibody Ki-67

Acc ID: CHEBI:63607 Term: linezolid Definition: An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex. CasRN: 165800-03-3 Chemical ID: MESH:C098010

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	linezolid results in decreased expression of MKI67 mRNA	PMID:21296123