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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2559
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:63580
Term: ribavirin
Definition: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses.
Chemical ID: MESH:D012254
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epoincreases expressionISOEPO (Homo sapiens)6480464CTDRibavirin results in increased expression of EPOPMID:12713065
Epomultiple interactionsISOEPO (Homo sapiens)6480464CTD[peginterferon alfa-2b co-treated with Ribavirin] affects the expression of EPO protein; [Ribavirin co-treated with Interferons] results in increased expression of EPO proteinPMID:15232364 PMID:20009130
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