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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737278 Species: Mus musculus RGD Object: Gene Symbol: Slc22a1 Name: solute carrier family 22 (organic cation transporter), member 1

Acc ID: CHEBI:63577 Term: lamivudine Definition: A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase. CasRN: 134678-17-4 Chemical ID: MESH:D019259

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases uptake	ISO	RGD:732626	6480464	CTD	SLC22A1 protein results in increased uptake of Lamivudine	PMID:19141712