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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10109 Species: Mus musculus RGD Object: Gene Symbol: Adrb2 Name: adrenergic receptor, beta 2

Acc ID: CHEBI:6343 Term: labetalol Definition: A secondary amino compound formally derived from ammonia by replacing two of the hydrogens by 2-(3-carbamoyl-4-hydroxyphenyl)-2-hydroxyethyl and 4-phenylbutan-2-yl groups. It is an adrenergic antagonist used to treat high blood pressure. CasRN: 36894-69-6 Chemical ID: MESH:D007741

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:733595	6480464	CTD	Labetalol results in decreased activity of ADRB2 protein	PMID:2567112
affects binding	ISO	RGD:2060	6480464	CTD	Labetalol binds to ADRB2 protein	PMID:11483288
multiple interactions	ISO	RGD:2060	6480464	CTD	Labetalol binds to and results in decreased activity of ADRB2 protein	PMID:11425575
multiple interactions	ISO	RGD:733595	6480464	CTD	[Labetalol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein [Labetalol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein	PMID:17925438
affects binding	ISO	RGD:2060	6480464	CTD	Labetalol binds to ADRB2 protein	PMID:2462161 PMID:11483288
multiple interactions	ISO	RGD:2060	6480464	CTD	Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein] Labetalol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]	PMID:2462161
affects binding	ISO	RGD:2060	6480464	CTD	Labetalol binds to ADRB2 protein	PMID:11483288 PMID:2462161