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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1a2 Name: cytochrome P450, family 1, subfamily a, polypeptide 2

Acc ID: CHEBI:6339 Term: etoricoxib Definition: A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively. CasRN: 202409-33-4 Chemical ID: MESH:C422649

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:735711	6480464	CTD	etoricoxib results in decreased activity of CYP1A2 protein	PMID:18816299