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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:61390
Term: afatinib
Definition: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer.
Chemical ID: MESH:C522924
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1decreases expressionISOPOU5F1 (Homo sapiens)6480464CTDafatinib results in decreased expression of POU5F1 proteinPMID:28787001
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTDafatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]PMID:28787001
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