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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305261 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp4f18 Name: cytochrome P450, family 4, subfamily f, polypeptide 18

Acc ID: CHEBI:6067 Term: isotretinoin Definition: A retinoic acid that has formula C20H28O2. CasRN: 4759-48-2 Chemical ID: MESH:D015474

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1347352	6480464	CTD	Isotretinoin results in decreased expression of CYP4F2 mRNA	PMID:20436886
decreases expression	ISO	RGD:1349362	6480464	CTD	Isotretinoin results in decreased expression of CYP4F3 mRNA	PMID:20436886