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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10123 Species: Mus musculus RGD Object: Gene Symbol: Agtr1b Name: angiotensin II receptor, type 1b

Acc ID: CHEBI:59877 Term: enalaprilat dihydrate Definition: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection. CasRN: 84680-54-6 Chemical ID: MESH:D015773

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:68977	6480464	CTD	Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein]	PMID:16452552