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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:5864 Term: ifosfamide Definition: A nitrogen mustard alkylating agent used in the treatment of cancer CasRN: 3778-73-2 Chemical ID: MESH:D007069

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects hydroxylation	EXP		6480464	CTD	CYP3A4 protein affects the hydroxylation of Ifosfamide	PMID:12136253
affects degradation	EXP		6480464	CTD	CYP3A4 protein affects the degradation of Ifosfamide	PMID:12136253
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Ifosfamide	PMID:15875221
decreases ethylation	EXP		6480464	CTD	CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide CYP3A4 protein results in decreased ethylation of Ifosfamide	PMID:15821045
increases response to substance	EXP		6480464	CTD	CYP3A4 protein results in increased susceptibility to Ifosfamide	PMID:20507880
increases response to substance	EXP		6480464	CTD	CYP3A4 results in increased susceptibility to Ifosfamide	PMID:9766669
increases expression	EXP		6480464	CTD	Ifosfamide results in increased expression of CYP3A4 mRNA	PMID:18839173