GENE - CHEMICAL INTERACTIONS REPORT
cytochrome P450, family 3, subfamily A, polypeptide 4
A nitrogen mustard alkylating agent used in the treatment of cancer
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
affects hydroxylation EXP 6480464 CTD CYP3A4 protein affects the hydroxylation of Ifosfamide PMID:12136253 affects degradation EXP 6480464 CTD CYP3A4 protein affects the degradation of Ifosfamide PMID:12136253 affects metabolic processing EXP 6480464 CTD CYP3A4 protein affects the metabolism of Ifosfamide PMID:15875221 decreases ethylation EXP 6480464 CTD CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide CYP3A4 protein results in decreased ethylation of Ifosfamide PMID:15821045 increases response to substance EXP 6480464 CTD CYP3A4 protein results in increased susceptibility to Ifosfamide PMID:20507880 increases response to substance EXP 6480464 CTD CYP3A4 results in increased susceptibility to Ifosfamide PMID:9766669 increases expression EXP 6480464 CTD Ifosfamide results in increased expression of CYP3A4 mRNA PMID:18839173