GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | affects binding | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | hyperforin binds to NR1I2 protein | PMID:27071811 | Nr1i2 | increases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | hyperforin results in increased activity of NR1I2 protein | PMID:15856409 PMID:26187274 | Nr1i2 | increases response to substance | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | NR1I2 protein results in increased susceptibility to hyperforin | PMID:26920453 | Nr1i2 | multiple interactions | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | [NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin binds to and results in increased activity of NR1I2 protein; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]; NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids] | PMID:14600250 PMID:15630458 PMID:20079722 PMID:26920453 | |
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