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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bincreases expressionEXP 6480464CTDHexachlorobenzene results in increased expression of CDKN1B proteinPMID:25093615
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTDHexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein]PMID:28215542
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