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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDHexachlorobenzene results in increased expression of TGFB1 mRNA; Hexachlorobenzene results in increased expression of TGFB1 proteinPMID:19182106 PMID:21787832 PMID:25093615 PMID:29277037
Tgfb1affects expressionISOTgfb1 (Mus musculus)6480464CTDHexachlorobenzene affects the expression of TGFB1 mRNAPMID:28923513
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDHexachlorobenzene results in increased expression of TGFB1 mRNAPMID:27519288
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]; Hexachlorobenzene results in increased expression of and results in increased cleavage of TGFB1 proteinPMID:27519288
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDHexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]PMID:28923513
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