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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:5441
Term: glyburide
Definition: An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Chemical ID: MESH:D005905
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrdecreases activityEXP 6480464CTDGlyburide results in decreased activity of CFTR proteinPMID:15236628 PMID:15389550 PMID:15654852 PMID:16012949
Cftrmultiple interactionsEXP 6480464CTDGlyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]PMID:17596272
Cftrdecreases activityISOCftr (Mus musculus)6480464CTDGlyburide results in decreased activity of CFTR proteinPMID:15650130 PMID:16012949
Cftrdecreases activityISOCFTR (Homo sapiens)6480464CTDGlyburide results in decreased activity of CFTR proteinPMID:14502435 PMID:15131065 PMID:15371258 PMID:15634668 PMID:15802612 PMID:16054561
Cftrmultiple interactionsISOCftr (Mus musculus)6480464CTDGlyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]; Glyburide inhibits the reaction [CFTR protein affects the transport of Chlorides]PMID:15650130
Cftrmultiple interactionsISOCFTR (Homo sapiens)6480464CTDGlyburide binds to and results in decreased activity of CFTR protein; Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]PMID:14967738 PMID:15857825 PMID:18230692 PMID:19061877
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