Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionISOTgfb1 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of TGFB1 proteinPMID:17015710
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDBAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]PMID:17015710
Go Back to source page   Continue to Ontology report