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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320 Species: Rattus norvegicus RGD Object: Gene Symbol: Mmp9 Name: matrix metallopeptidase 9

Acc ID: CHEBI:53556 Term: toluene 2,4-diisocyanate Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring. CasRN: 584-84-9 Chemical ID: MESH:D014051

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731911	6480464	CTD	epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein] epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]	PMID:16516891
increases activity	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased activity of MMP9 protein	PMID:11742282
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA	PMID:15131573 PMID:14987308 PMID:12789230 PMID:16516891
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein	PMID:15131573 PMID:12789230 PMID:14987308
decreases expression	ISO	RGD:1348437	6480464	CTD	Toluene 2,4-Diisocyanate results in decreased expression of MMP9 protein	PMID:12534559
multiple interactions	ISO	RGD:731911	6480464	CTD	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA] Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA] 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein] Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]	PMID:15131573
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein	PMID:14987308 PMID:12789230 PMID:15131573
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA	PMID:16516891 PMID:15131573 PMID:12789230 PMID:14987308
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA	PMID:16516891 PMID:12789230 PMID:14987308 PMID:15131573
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA	PMID:12789230 PMID:14987308 PMID:15131573 PMID:16516891
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein	PMID:15131573 PMID:14987308 PMID:12789230
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein	PMID:12789230 PMID:15131573 PMID:14987308
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA	PMID:16516891 PMID:12789230 PMID:15131573 PMID:14987308
increases expression	ISO	RGD:731911	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein	PMID:12789230 PMID:14987308 PMID:15131573