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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353278 Species: Homo sapiens RGD Object: Gene Symbol: CCL4 Name: chemokine (C-C motif) ligand 4

Acc ID: CHEBI:53556 Term: toluene 2,4-diisocyanate Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring. CasRN: 584-84-9 Chemical ID: MESH:D014051

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1550761	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of CCL4 protein	PMID:20219652
increases expression	ISO	RGD:1550761	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of CCL4 mRNA	PMID:19647056