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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:53212
Term: isocyanates
Definition: Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).
Chemical ID: MESH:D017953
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDIsocyanates results in increased expression of H2AX proteinPMID:19283680
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDIsocyanates analog results in increased phosphorylation of H2AX proteinPMID:19111005
H2axincreases phosphorylationISOH2ax (Mus musculus)6480464CTD[Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AX proteinPMID:19197993
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