GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730895
Species: Mus musculus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: CHEBI:53053
Term: 1-chloro-2,4,6-trinitrobenzene
Definition: A chlorobenzene compound with three nitro substituents in the 2-, 4- and 6-positions.
CasRN: 88-88-0
Chemical ID: MESH:D010853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7308946480464CTDCASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL18 protein]

PMID:17429439
increases cleavageISORGD:7308946480464CTDPicryl Chloride results in increased cleavage of IL18 protein

PMID:17429439
multiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]

Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]

Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]

PMID:16442096
increases expressionEXP 6480464CTDPicryl Chloride results in increased expression of IL18 protein

PMID:16442096
PMID:15734285
increases expressionEXP 6480464CTDPicryl Chloride results in increased expression of IL18 protein

PMID:15734285
PMID:16442096
multiple interactionsEXP 6480464CTDanthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]

anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]

PMID:20381601
increases expressionEXP 6480464CTDPicryl Chloride results in increased expression of IL18 mRNA

PMID:20381601
increases secretionEXP 6480464CTDPicryl Chloride results in increased secretion of IL18 protein

PMID:20381601
Go Back to source page   Continue to Ontology report