GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c79 | decreases activity | ISO | CYP2C8 (Homo sapiens) | 6480464 | CTD | Gemfibrozil metabolite results in decreased activity of CYP2C8 protein; Gemfibrozil results in decreased activity of CYP2C8 protein | PMID:15771232 PMID:16042675 | Cyp2c79 | decreases expression | ISO | CYP2C8 (Homo sapiens) | 6480464 | CTD | Gemfibrozil results in decreased expression of CYP2C8 protein | PMID:15771232 PMID:29960002 | Cyp2c79 | increases expression | ISO | CYP2C8 (Homo sapiens) | 6480464 | CTD | Gemfibrozil results in increased expression of CYP2C8 mRNA | PMID:15771232 | Cyp2c79 | multiple interactions | ISO | CYP2C8 (Homo sapiens) | 6480464 | CTD | [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite; [Gemfibrozil results in decreased activity of CYP2C8 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone] | PMID:15771232 PMID:15900286 PMID:21277363 | | ||||||||||||||||||||||
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