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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159 Species: Mus musculus RGD Object: Gene Symbol: Casp9 Name: caspase 9

Acc ID: CHEBI:5292 Term: geldanamycin Definition: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. it is an ansamycin antibiotic and thus shows antimicrobial activity against many gram-positive and some gram-negative bacteria. CasRN: 30562-34-6 Chemical ID: MESH:C001277

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69147	6480464	CTD	geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]	PMID:16311509