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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp6
Name: caspase 6
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp6increases cleavageISOCASP6 (Homo sapiens)6480464CTDBortezomib results in increased cleavage of CASP6 proteinPMID:16617327
Casp6multiple interactionsISOCASP6 (Homo sapiens)6480464CTDBortezomib promotes the reaction [TNFSF10 protein results in increased cleavage of CASP6 protein]; SCIO-469 promotes the reaction [Bortezomib results in increased cleavage of CASP6 protein]PMID:16617327 PMID:17510429
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