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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:5262
Term: galangin
Definition: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Chemical ID: MESH:C037032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1multiple interactionsEXP 6480464CTDgalangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein]PMID:35384154
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTDgalangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased activity of CASP1 protein]PMID:23535185
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