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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731056 Species: Homo sapiens RGD Object: Gene Symbol: INS Name: insulin

Acc ID: CHEBI:52289 Term: wortmannin Definition: A delta-lactone that has formula C23H24O8. CasRN: 19545-26-7 Chemical ID: MESH:C009687

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]	PMID:11574405
multiple interactions	EXP		6480464	CTD	wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]	PMID:17550345
multiple interactions	ISO	RGD:2916	6480464	CTD	wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]	PMID:17728140
multiple interactions	EXP		6480464	CTD	wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids]	PMID:20015842