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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases reactionEXP 152177689RGDwortmannin inhibits the reaction [estrogen increases expression of Vegfa mRNA] in rat uterus 
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of VEGFA mRNA]PMID:13679210 PMID:15050414 PMID:16499871 PMID:18252963 PMID:18790786 PMID:22841774 PMID:23968725 PMID:30217479 PMID:36190352
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