• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731644 Species: Homo sapiens RGD Object: Gene Symbol: RPS6KB1 Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1

Acc ID: CHEBI:52288 Term: lysophosphatidic acid Definition: LPA is a phospholipid derivative that acts as a potent signaling molecule. LPA acts as a potent mitogen due to its activation of three high-affinity GPCRs. CasRN: 22002-87-5 Chemical ID: MESH:C032881

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases phosphorylation	EXP		6480464	CTD	lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein	PMID:17919812
multiple interactions	ISO	RGD:620683	6480464	CTD	1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein] exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]	PMID:14769825
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]	PMID:17919812
increases phosphorylation	ISO	RGD:620683	6480464	CTD	lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein	PMID:14769825