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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991 Species: Rattus norvegicus RGD Object: Gene Symbol: Vegfa Name: vascular endothelial growth factor A

Acc ID: CHEBI:52288 Term: lysophosphatidic acid Definition: LPA is a phospholipid derivative that acts as a potent signaling molecule. LPA acts as a potent mitogen due to its activation of three high-affinity GPCRs. CasRN: 22002-87-5 Chemical ID: MESH:C032881

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:731072	6480464	CTD	[lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA [lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA protein	PMID:17919812
multiple interactions	ISO	RGD:731072	6480464	CTD	resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of VEGFA protein]	PMID:17919812