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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353194 Species: Homo sapiens RGD Object: Gene Symbol: CXCR1 Name: chemokine (C-X-C motif) receptor 1

Acc ID: CHEBI:52288 Term: lysophosphatidic acid Definition: LPA is a phospholipid derivative that acts as a potent signaling molecule. LPA acts as a potent mitogen due to its activation of three high-affinity GPCRs. CasRN: 22002-87-5 Chemical ID: MESH:C032881

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	lysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein] lysophosphatidic acid results in decreased expression of [CXCR1 protein binds to LPAR1 protein]	PMID:16224106
decreases expression	EXP		6480464	CTD	lysophosphatidic acid results in decreased expression of CXCR1 mRNA	PMID:16224106