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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:517248
Term: bufalin
Definition: A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.
Chemical ID: MESH:C022777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDbufalin results in decreased expression of MMP2 mRNAPMID:23949904
Mmp2decreases secretionISOMMP2 (Homo sapiens)6480464CTDbufalin results in decreased secretion of MMP2 proteinPMID:23949904
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDbufalin results in decreased expression of and results in decreased activity of MMP2 proteinPMID:21922632 PMID:23949904
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