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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:5147 Term: formoterol Definition: A racemate consisting of equal amounts of arformoterol (the active enantiomer) and (S,S)-formoterol (the inactive enantiomer). Its fumaric acid salt is used as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema). CasRN: 73573-87-2 Chemical ID: MESH:C012629

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10790	6480464	CTD	[TNF protein co-treated with IL1B protein] results in decreased susceptibility to formoterol Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to formoterol]	PMID:20061444