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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:51348
Term: tetraphene
Definition: An angular ortho-fused polycyclic arene consisting of four fused benzene rings.
Chemical ID: MESH:C030935
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects response to substanceEXP 6480464CTDCYP1A2 protein affects the susceptibility to benz(a)anthracenePMID:21384493
Cyp1a2increases expressionEXP 6480464CTDbenz(a)anthracene results in increased expression of CYP1A2 mRNAPMID:21384493 PMID:23358148
Cyp1a2multiple interactionsEXP 6480464CTD[chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A2 mRNA; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNAPMID:37189300
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDbenz(a)anthracene results in decreased activity of CYP1A2 proteinPMID:11162773
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDbenz(a)anthracene results in increased expression of CYP1A2 mRNAPMID:17825862
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDbenz(a)anthracene results in increased expression of CYP1A2 mRNAPMID:17253728 PMID:9783729
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of benz(a)anthracene; [fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA; EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benz(a)anthracene]PMID:17825862 PMID:7750161 PMID:8961944
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of benz(a)anthracene; EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benz(a)anthracene]PMID:8961944
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