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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:51348
Term: tetraphene
Definition: An angular ortho-fused polycyclic arene consisting of four fused benzene rings.
Chemical ID: MESH:C030935
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects bindingEXP 6480464CTDbenz(a)anthracene binds to AHR proteinPMID:15071172 PMID:3024361
Ahrincreases activityEXP 6480464CTDbenz(a)anthracene results in increased activity of AHR proteinPMID:18205319
Ahrincreases response to substanceEXP 6480464CTDAHR results in increased susceptibility to benz(a)anthracenePMID:17141280
Ahrmultiple interactionsEXP 6480464CTDAHR affects the reaction [benz(a)anthracene results in increased expression of CCNA2 protein]; AHR affects the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; benz(a)anthracene binds to and results in increased activity of AHR protein; benz(a)anthracene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]PMID:12850102 PMID:17141280 PMID:20634293 PMID:3005314 PMID:3024361
Ahraffects bindingISOAHR (Homo sapiens)6480464CTDbenz(a)anthracene binds to AHR proteinPMID:1650214 PMID:1654865 PMID:25329374
Ahraffects response to substanceISOAhr (Mus musculus)6480464CTDAHR affects the susceptibility to benz(a)anthracenePMID:12117779
Ahrincreases activityISOAHR (Homo sapiens)6480464CTDbenz(a)anthracene results in increased activity of AHR proteinPMID:17665671 PMID:23396138
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDAHR protein affects the reaction [benz(a)anthracene inhibits the reaction [EGF protein binds to EGFR protein]]; benz(a)anthracene binds to and results in increased activity of AHR protein; benz(a)anthracene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]PMID:1658612 PMID:3005314 PMID:6309801
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTD[benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with TNF protein] results in increased activity of AHR protein; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; AHR protein affects the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6]; AHR protein affects the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; AHR protein promotes the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; benz(a)anthracene promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]PMID:17665671 PMID:2154949 PMID:21781905 PMID:23396138
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