GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a9 | affects response to substance | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein affects the susceptibility to Fluticasone | PMID:20707410 | Cyp3a9 | decreases activity | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Fluticasone results in decreased activity of CYP3A5 protein | PMID:20707410 | Cyp3a9 | increases expression | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Fluticasone results in increased expression of CYP3A5 mRNA | PMID:24555085 | Cyp3a9 | increases metabolic processing | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | CYP3A5 protein results in increased metabolism of Fluticasone | PMID:20707410 | Cyp3a9 | multiple interactions | ISO | CYP3A5 (Homo sapiens) | 6480464 | CTD | Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA] | PMID:24555085 | | ||||||||||||||||||||||
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