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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDFlutamide results in decreased activity of GSR proteinPMID:23135684
Gsrincreases expressionEXP 6480464CTDFlutamide results in increased expression of GSR mRNAPMID:24136188
Gsrmultiple interactionsEXP 6480464CTDdaidzein inhibits the reaction [Flutamide results in decreased activity of GSR protein]PMID:23135684
Gsrincreases expressionISOGsr (Mus musculus)6480464CTDFlutamide results in increased expression of GSR mRNAPMID:17702527
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