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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2033
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adarb1
Name: adenosine deaminase, RNA-specific, B1
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adarb1increases expressionISOAdarb1 (Mus musculus)6480464CTDFluoxetine results in increased expression of ADARB1 mRNA; Fluoxetine results in increased expression of ADARB1 proteinPMID:21320410
Adarb1multiple interactionsISOAdarb1 (Mus musculus)6480464CTDADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; ADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; ADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]PMID:21320410
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