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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3increases phosphorylationISOEIF2AK3 (Homo sapiens)6480464CTDsorafenib results in increased phosphorylation of EIF2AK3 proteinPMID:17548474
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTD[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to EIF2AK3 protein]; [sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein]; FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]; FAS protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]PMID:18787411
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