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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases activityISOTGFB1 (Homo sapiens)6480464CTDsorafenib results in decreased activity of TGFB1 proteinPMID:21360571
Tgfb1decreases activityISOTgfb1 (Mus musculus)6480464CTDsorafenib results in decreased activity of TGFB1 proteinPMID:21360571
Tgfb1decreases expressionISOTgfb1 (Mus musculus)6480464CTDsorafenib results in decreased expression of TGFB1 mRNAPMID:21360571
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDSorafenib inhibits the reaction [Oleic Acid results in increased expression of TGFB1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased activity of CASP3 mRNA]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]PMID:21360571 PMID:32918399
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDSorafenib inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]PMID:21360571 PMID:29859236
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