GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2l1 | decreases expression | ISO | BCL2L1 (Homo sapiens) | 6480464 | CTD | Sorafenib results in decreased expression of BCL2L1 protein | PMID:16109713 PMID:17991738 PMID:19633425 PMID:26911335 | Bcl2l1 | multiple interactions | ISO | BCL2L1 (Homo sapiens) | 6480464 | CTD | [sorafenib co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; BCL2L1 protein inhibits the reaction [sorafenib affects the folding of and results in increased activity of BAX protein]; BCL2L1 protein inhibits the reaction [sorafenib results in increased cleavage of and results in increased activity of CASP3 protein]; resveratrol promotes the reaction [sorafenib results in decreased expression of BCL2L1 protein]; sorafenib promotes the reaction [destruxin B results in decreased expression of BCL2L1 protein] | PMID:17909059 PMID:19366808 PMID:24434019 PMID:26911335 | |
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