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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940 Species: Mus musculus RGD Object: Gene Symbol: Myc Name: myelocytomatosis oncogene

Acc ID: CHEBI:50729 Term: mitoxantrone Definition: A hydroxyanthraquinone that has formula C22H28N4O6. CasRN: 65271-80-9 Chemical ID: MESH:D008942

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:731438	6480464	CTD	Mitoxantrone results in decreased expression of MYC mRNA	PMID:8219202
multiple interactions	ISO	RGD:731438	6480464	CTD	Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]	PMID:8219202